卓越教授B岗

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  • 贺文琦教授
  • 性别:男
  • 职称:教授
  • 硕导/博导:博导
  • 学科专业:基础兽医学
  • 最高学位:博士
  • 研究方向:动物传染病病理和肿瘤病理,涉及动物病毒感染及致病机制、肿瘤诊断与抗肿瘤药物研究
  • 最高学历:研究生
  • 邮箱:hewq@jlu.edu.cn

讲授课程

本科生:动物病理解剖学、食品卫生病理学

硕士生:兽医病理组织学、动物疾病病变鉴别诊断学

教育经历

1997-2001,内蒙古农业大学,动物医学,本科

2001-2004,中国人民解放军军需大学,预防兽医学,硕士

2006-2009,最全菠菜导航网,基础兽医学,博士

工作经历

2020-至今,最全菠菜导航网,“唐敖庆学者”卓越教授B岗

2017-至今,51菠菜网,副经理

2017-至今,国家级动物科技实验教学示范中心,主任

2013-至今,最全菠菜导航网,教授

2011-2012,美国佐治亚大学,博士后

2004-2013,最全菠菜导航网,助教、讲师、副教授

科研项目

1. 国家自然基金面上项目,神经细胞内质网应激在PHEV感染过程中的作用及其机制(32172828) 2022.1-2025.12,

2. 国家自然基金面上项目,PHEV入侵神经细胞胞吞途径及其胞内运输的分子机制(31772704) 2018.1-2021.12

3. 国家自然基金面上项目,胶质细胞在猪血凝性脑脊髓炎病毒感染CNS中的免疫应答机制(31472194) 2015.1-2018.12

4. 国家自然基金面上项目,猪血凝性脑脊髓炎病毒感染过程中的免疫应答机制研究(31172291) 2012.1-2015.12

5. 国家自然基金青年基金,川金丝猴源柯萨奇B3病毒感染猕猴的病理及血液指标变化特征(30901060) 2010.1-2012.12

6. 国家重点研发计划项目子课题,仔猪腹泻冠状病毒感染及其致病机理(2016YFD0500102) 2016.1-2020.12

7. 吉林省重点研发项目,猪血凝性脑脊髓炎病毒DNA疫苗的研制及其免疫保护力评价(20210202041NC),2021.7-2024.6

8. 吉林省自然科学基金项目,内吞介导猪血凝性脑脊髓炎病毒侵入神经细胞的分子机制(20180101270JC) 2018.1-2020.12

9. 吉林省自然科学基金项目,猪血凝性脑脊髓炎病毒感染小鼠脑组织microRNA组学研究(20130101106JC) 2013.1-2015.12

学术论文

2016年以来发表的代表性文章:

1. The PERK/PKR-eIF2α pathway negatively regulates porcine hemagglutinating encephalomyelitis virus replication by attenuating global protein translation and facilitating stress granule formation. Journal of Virology. 2022-01-12, J Virol 96:1: e01695-21.

2. Evidence of microglial immune response following coronavirus PHEV infection of CNS. Frontiers in Immunology, 2022-01-10, 12, 804625. DOI: 10.3389/fimmu.2021.804625.

3. Cell-surface glycans act as attachment factors for porcine hemagglutinating encephalomyelitis virus. Veterinary Microbiology. 2022 Feb, 265: 109315.

4. Microtubule depolymerization limits porcine betacoronavirus PHEV replication. Veterinary Microbiology. 2022 April 27, 269: 109448.

5. Porcine Haemagglutinating Encephalomyelitis Virus Triggers Neural Autophagy Independent of ULK1. Journal of Virology. 2021 Sep 9; 95(19): e00851-21. pp.JVI0085121.

6. Orf virus ORF120 protein positively regulates the NF-κB pathway by interacting with G3BP1. Journal of Virology. 2021 Sep 9; 95(19): e00153-21.

7. Prevalence and Characterization of Cryptosporidium Species in Tibetan Antelope (Pantholops hodgsonii). Frontiers in Cellular and Infection Microbiology, 2021, 11:713873. doi: 10.3389/fcimb.2021.713873.

8. Host factor cyclophilin B affects Orf virus replication by interacting with viral ORF058 protein. Veterinary Microbiology, July 2021, 258: 109099.

9. Porcine hemagglutinating encephalomyelitis virus induces atypical autophagy via opposite regulation of expression and nuclear translocation of transcription factor EB. Veterinary Microbiology, 2021 Apr; 255:109015.

10. DDIT3 targets innate immunity via the DDIT3-OTUD1-MAVS pathway to promote bovine viral diarrhea virus replication. Journal of Virology. 2021. J Virol 95: e02351-20.

11. Porcine Haemagglutinating Encephalomyelitis Virus Deactivates Transcription Factor IRF3 and Limits Type I Interferon Production. Veterinary Microbiology, 2021 Jan; 252: 108918.

12. miR-142a-3p promotes the proliferation of porcine hemagglutinating encephalomyelitis virus by targeting Rab3a. Archives of Virology, 2020 Feb; 165(2):345-354.

13. MiR-10a-5p-Mediated Syndecan 1 Suppression Restricts Porcine Hemagglutinating Encephalomyelitis Virus Replication. Frontiers in Microbiology. 2020, 11: 105.

14. An experimental model of neurodegenerative disease based on porcine hemagglutinating encephalomyelitis virus-related lysosomal abnormalities. Molecular Neurobiology. 2020 Sep 2, 57(12): 5299-5306.

15. Porcine hemagglutinating encephalomyelitis virus activation of the integrin α5β1-FAK-Cofilin pathway causes cytoskeletal rearrangement to promote its invasion of N2a cells. Journal of Virology. 2019 Feb 19; 93(5). pii: e01736-18.

16. ATN-161 reduces virus proliferation in PHEV-infected mice by inhibiting the integrin α5β1-FAK signaling pathway. Veterinary Microbiology, 2019 Jun; 233: 147-153.

17. Cellular microRNA bta-miR-2361 inhibits bovine herpesvirus 1 replication by directly targeting EGR1 gene. Veterinary Microbiology, 2019 Jun; 233: 174-183.

18. Genomic characterization of two Orf virus isolates from Jilin province in China. Virus Genes, 2019 Aug; 55(4):490-501.

19. Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders. Journal of Virology. 2018 Jul 31; 92(16). pii: e00325-18.

20. Genomic characterization and pathogenicity of a porcine hemagglutinating encephalomyelitis virus strain isolated in China. Virus Genes. 2018 Oct;54(5):672-683.

21. Porcine hemagglutinating encephalomyelitis virus enters Neuro-2a cells via clathrin-mediated endocytosis in a Rab5-, cholesterol-, and pH-dependent manner. Journal of Virology. 2017 Nov 14; 91(23). pii: e01083-17.

22. Induction of atypical autophagy by porcine hemagglutinating encephalomyelitis virus contributes to viral replication. Frontiers in Cellular and Infection Microbiology. 2017, 7:56.

23. miR-21a-5p contributes to porcine hemagglutinating encephalomyelitis virus proliferation via targeting CASK-interactive protein1 in vivo and vitro. Frontiers in Microbiology. 2017, 8: 304.

24. miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1. Frontiers in Cellular and Infection Microbiology. 2017 May 3; 7:155.

25. Cyclophilin B facilitates the replication of Orf virus. Virology Journal. 2017, Jun 15; 14(1): 114.

26. Baicalin Protects Mice from Lethal Infection by Enterohemorrhagic Escherichia coli. Frontiers in Microbiology. 2017, 8:395.

27. The matrix protein of vesicular stomatitis virus inhibits host-directed transcription of target genes via interaction with the TFIIH subunit p8. Veterinary Microbiology, 2017 Sep; 208: 82-88.

28. EIF3i Affects Vesicular Stomatitis Virus Growth by Interacting with Matrix Protein. Veterinary Microbiology, 2017 Dec; 212: 59-66.

29. Development of a lateral flow immunochromatographic assay for the rapid diagnosis of Orf virus infections. Journal of Virological Methods. 2016, Jul 2; 236:10-17.

30. The evidence of porcine hemagglutinating encephalomyelitis virus induced nonsuppurative encephalitis as the cause of death in piglets. 2016, PeerJ. 2016 Sep 15; 4:e2443.

31. Role of autophagy in cellular response to infection with Orf virus Jilin isolate. Veterinary Microbiology, 2016 Sep 25; 193: 22-27.

著作教材

1. 主编,《动物病理解剖学》(第二版),科学出版社 2013.11

2. 主编,《动物疾病病理诊断学》,科学出版社 2010.01

3. 主编,《动物病理解剖学》,科学出版社 2008.08

4. 副主编,《动物病理学》(双语),浙江大学出版社,2020.11.

5. 副主译,《马血液与细胞诊断学》(第2版)(译著),中国农业出版社,2019.06.

6. 副主编,《动物形态学实验指导》,最全菠菜导航网出版社 2010.01

7. 参编,《动物冠状病毒病》,中国农业出版社,2021.05.

8. 参编,《家畜病理学》(第5版),中国农业出版社,2016.05.

9. 参编,《兽医病理学》(第5版)(译著),中国农业出版社,2015.12;

10. 参编,《猪病学》(第十版)(译著),中国农业大学出版社2014.08

11. 参编,《动物病理解剖学》,化学工业出版社 2011.08

12. 参编,《野生动物疫病学》,高等教育出版社 2011.05

13. 参编,《畜牧兽医专业英语听力教程》,复旦大学出版社 2009.08

14. 参编,《犬病/兽医全攻略》,中国农业出版社2009.08

获奖情况

1. 吉林省首批科研“春苗”人才称号;

2. 吉林省自然科学奖二等奖1项;

3. 吉林省自然科学学术成果奖一等奖1项、二等奖2项;

4. 吉林省教学成果一等奖、吉林省高等学校优秀教材奖、吉林省精品课程、最全菠菜导航网教学成果特等奖等教学成果奖7项;

5. 吉林省省级虚拟仿真实验教学一流课程;

6. 吉林省硕士专业学位示范论文指导教师;

7. 全国老员工动物医学专业技能大赛特等奖3次,指导教师。

社会兼职

1. 中国病理生理学会,理事;

2. 中国病理生理学会动物病理生理学专业委员会,副主任委员;

3. 中国畜牧兽医学会兽医病理学分会,常务理事;

4. 中国畜牧兽医学会动物传染病学分会,理事;

5. 中国畜牧兽医学会生物技术学分会,理事;

6. 吉林省畜牧兽医学会,常务理事;

7. 吉林省神经科学学会,理事;

8. 吉林省高等学校教指委委员;

9. 吉林省畜牧业标准化技术委员会委员;

10. 吉林省动物疫病防控专家;

11. 《中国兽医学报》期刊编委;

12. 《Frontiers in Cellular and Infection Microbiology》期刊Review Editor。

联系我们

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动物医院电话:0431-87836297 或 87836298

地址:吉林省长春市西安大路5333号